Association study of schizophrenia spectrum disorders and dopamine D3 receptor gene: is schizoaffective disorder special?
نویسندگان
چکیده
Alterations in dopamine neurotransmission have been hypothesized to play a role in the etiology of schizophrenia. We considered the dopamine D3 receptor gene on chromosome 3 as a candidate gene for an association analysis. We compared PCR-based genotype markers for healthy controls (n=120) and patients (n=95) with schizophrenia and schizophrenia spectrum disorders as diagnosed by consensus according to DSM-III-R. Our results possibly indicate an association of schizoaffective disorder with DRD3 homozygosity (P=0.056).
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ورودعنوان ژورنال:
- Psychiatry research
دوره 96 2 شماره
صفحات -
تاریخ انتشار 2000